Mounjaro weight loss reviews: Real user experiences and results
Thinking about trying Mounjaro for weight loss? See what others are saying – the good, the bad, and the unexpected.
Key highlights
- Mounjaro is an FDA-approved prescription drug for controlling blood sugar levels in people with type 2 diabetes and is also used off-label for weight loss in people with obesity or overweight.
- Mounjaro can be expensive, with a retail price of $1,000-$1,200/month, although savings card programs and insurance coverage may help reduce costs.
- Many users report positive experiences, citing significant weight loss, improved energy, and reduced cravings. However, some note side effects like nausea and other gastrointestinal issues.
- To maximize weight loss, Mounjaro should be combined with a healthy diet, regular exercise, and consistent use, as long-term results depend on ongoing lifestyle changes.
- Always consult your doctor to see if Mounjaro is right for you, especially if you have pre-existing health conditions.
Did you know that over 40% of Americans in the U.S. have obesity, and over 38 million people have type 2 diabetes? As these numbers continue to rise, GLP-1 medications like Mounjaro have become increasingly popular for managing blood sugar levels and aiding in weight loss.
Mounjaro (tirzepatide) is a popular FDA-approved injectable medication for type 2 diabetes. Mounjaro is not approved for weight loss but some doctors may prescribe it off-label to help with weight management in people with obesity (body mass index of 30 or more) and overweight (body mass index of 27 or more) with other weight-related conditions.
User feedback helps make informed decisions about weight loss treatments like Mounjaro, as it provides real-life insights into effectiveness and potential side effects.
Keep reading for an in-depth look at Mounjaro’s weight loss reviews to help you make an informed decision about your weight loss journey with Mounjaro. Discover real user experiences, results, benefits, side effects, costs, and expert opinions.
Understanding Mounjaro for weight loss
Mounjaro (tirzepatide) is a prescription injectable medication approved by the U.S. FDA in 2022 to help control blood sugar levels in people with type 2 diabetes. It is also prescribed off-label for weight loss in people with obesity or overweight when combined with diet and exercise.
Tirzepatide, also known by the brand names Mounjaro and Zepbound, is an FDA-approved dual-action GLP-1/GIP receptor agonist made by Eli Lilly.
Mounjaro is part of the GLP-1 drug family, but it’s unique because it mimics two gut hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors agonist.
This dual action may make Mounjaro more effective for weight loss and blood glucose control in comparison with other GLP-1 medications that target only one receptor (GLP-1), like Ozempic and Wegovy.
Mounjaro works by activating GLP-1 and GIP receptors in the brain and the pancreas. This helps regulate insulin after meals, controls blood sugar, slows stomach emptying, and reduces appetite, which leads to eating less and consequently losing weight.
Also, Mounjaro lowers HbA1c, a measure of long-term blood sugar control, by making the body more insulin-sensitive. This means cells take in sugar from the blood faster, less calories in, and less fat stored. It also reduces hunger and cravings by releasing hormones that make you feel full. By being more insulin-sensitive, it burns fat and stops fat from building up in cells.
Studies show that Mounjaro can help you lose significant body fat and weight, and boost metabolism and fat burning. It also improves cholesterol, blood sugar levels, and reduces hunger and food cravings.
In a study that compared Ozempic vs Mounjaro, Mounjaro (in doses of 5 mg, 10 mg, and 15 mg) worked more effectively than the 1 mg dose of Ozempic. Mounjaro improved blood sugar control and helped people lose more weight. For example, people taking the 15 mg dose of Mounjaro lost nearly twice as much weight as those on Ozempic.
A study found that over 18 months, people with type 2 diabetes who took 15 mg of tirzepatide (the active ingredient in Mounjaro) lost an average of 18% of their body weight, compared to 12.4% for those taking 2.4 mg of semaglutide.
A head-to-head trial comparing semaglutide and tirzepatide shows that tirzepatide promotes significantly more weight loss than semaglutide. People taking tirzepatide showed an average weight loss of 20.2% vs. 13.7% with semaglutide.
Pros and cons of using Mounjaro for weight loss
Pros
- Many users experience substantial weight loss, with some losing up to 20% of their body weight when combined with a healthy lifestyle.
- Mounjaro helps regulate blood sugar levels, making it beneficial for people with type 2 diabetes.
- Mounjaro lowers HbA1c which is a measure of long-term blood sugar control. By increasing insulin sensitivity, it helps people with type 2 diabetes manage their blood sugar over time.
- Mounjaro reduces hunger and increases feelings of fullness, so you eat less and lose weight. This is great for people with obesity or those who are overweight as it can lead to significant weight loss and a reduced risk of weight-related health conditions.
- The medication helps curb hunger and reduce cravings, making it easier to stick to a healthier eating plan.
- Although it is still being studied for heart health benefits, Mounjaro has shown promise in improving cardiovascular risk factors, such as weight loss and blood pressure reduction, but is not yet FDA-approved for cardiovascular benefits. The SURPASS-CVOT trial is ongoing to evaluate the cardiovascular outcomes of tirzepatide in patients with Type 2 diabetes.
- By controlling blood sugar and weight loss, Mounjaro reduces heart disease risk and improves overall metabolic wellness. This means better cholesterol, blood pressure, and a healthier heart.
Cons
- While Mounjaro can help lower blood sugar levels and promote weight loss, it’s important to be aware of possible side effects and safety tips when using this medication.
- The most common side effects of Mounjaro may include: Nausea, diarrhea, vomiting, decreased appetite, constipation, upset stomach, headache, and abdominal (stomach) pain.
- Mounjaro can be expensive, and insurance coverage may not always be available, especially when it’s prescribed off-label for weight loss.
- Since Mounjaro is not FDA-approved for weight loss, using it off-label raises potential risks, and its long-term effects are not fully known.
Mounjaro weight loss reviews: A comprehensive analysis
Patients rated Mounjaro injection for obesity and overweight 8.9/10 on Drugs.com, based on 405 user reviews and 388 ratings at the time of publishing this article. Out of 388 reviews for the treatment of weight loss (obesity/overweight), 84% of users had a positive experience, while only 4% had reported a negative experience.
Additionally, users have given an overall rating of 4.2 on WebMD. As the individual response to the medication may vary, there are different opinions about Mounjaro concerning its effectiveness, ease of use, and level of satisfaction.
Mounjaro weight loss results: What to expect
In clinical trials, Mounjaro has shown significant weight loss results. A study found that over 18 months, people with type 2 diabetes who took 15 mg of tirzepatide (the active ingredient in Mounjaro) lost an average of 18% of their body weight, compared to 12.4% for those taking 2.4 mg of semaglutide.
Another study compared the highest dose of Ozempic (2 mg) with the 5 mg, 10 mg, and 15 mg doses of Mounjaro. Those on the higher doses of Mounjaro (10 mg and 15 mg) lost more weight and had better blood sugar control than those taking the 2 mg dose of Ozempic.
Many users report steady weight loss in the initial months, with some seeing noticeable changes within the first 3-6 months. Improved energy levels and reduced cravings are commonly reported experiences, which can support long-term weight loss efforts.
Factors influencing individual results
Several factors can impact how much weight you lose with Mounjaro:
- Starting weight: Heavier individuals may see more significant initial weight loss compared to those with less excess weight.
- Adherence: Taking the medication as directed is essential for seeing the best results.
- Lifestyle changes: Diet and exercise are key to getting the most out of Mounjaro. Those who follow a healthy diet and exercise regularly tend to see better weight loss results.
- Other health conditions: Conditions like thyroid issues, metabolic problems, or medication interactions can impact weight loss.
You’ll likely need to take Mounjaro long term to maintain weight loss as stopping the medication may lead to weight gain.
Like any weight loss medication, there’s a chance you’ll regain weight after stopping the medication. To minimize this risk, you need to make long-term lifestyle changes including a healthy diet, regular exercise, and behavioral changes to support ongoing weight management.
Mounjaro side effects reviews: User-reported experiences
While Mounjaro can help with lowering blood sugar levels and promote weight loss, it’s important to be aware of possible side effects and safety tips when using this medication.
The most common side effects of Mounjaro may include:
- Nausea
- Diarrhea
- Vomiting
- Decreased appetite
- Constipation
- Upset stomach
- Headache
- Abdominal (stomach) pain
Other rare and more serious side effects of Mounjaro may include:
- Blurred or changed vision
- Low blood sugar (hypoglycemia)
- Gallbladder problems
- Depression or anxiety
- Serious allergic reactions
- Pancreatitis (Inflammation of the pancreas)
- Injection site reactions
If you experience any of these side effects, speak with your doctor right away.
Mounjaro has a black box warning from the FDA for the risk of thyroid tumors or thyroid cancer.
You should not use Mounjaro if you:
- Are allergic to tirzepatide or any of the ingredients
- Have a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Are pregnant or planning to become pregnant
- Are breastfeeding, as it is not known if Mounjaro passes into breast milk
- Have serious kidney or liver problems
- Have a severe gastrointestinal disease such as gastroparesis (delayed stomach emptying)
Tips to manage side effects
Here are some tips to manage the side effects of Mounjaro and make it easier to continue your treatment:
- Eat smaller meals more often: Instead of big meals, eat smaller meals throughout the day. This will help with nausea and stomach upset.
- Stay hydrated: Drink lots of water to help with digestion and prevent dehydration especially if you’re having diarrhea.
- Avoid heavy, greasy, or spicy food: These types of food will cause stomach discomfort and digestive issues worse.
- Take as directed: Follow your healthcare provider’s instructions and try to take the medication on the same day every week.
- Rest when you need to: If you’re feeling nauseous or tired, let your body rest and recover.
- Talk to your doctor: If side effects persist or become too uncomfortable, talk to your doctor for advice on managing them or potentially changing your treatment plan.
Mounjaro cost and affordability
Mounjaro can be expensive. The list price of Mounjaro is $1,069.08 per fill, according to the manufacturer, Eli Lilly. Each fill includes 4 prefilled pens, which is a 28-day supply. Without insurance, the retail price is estimated to be around $1,000-$1,200 per month.
Getting Mounjaro covered by insurance may be difficult, especially if prescribed off-label for weight loss. Insurance companies often prioritize coverage for Mounjaro when prescribed for type 2 diabetes but may not cover it for weight management unless certain criteria are met, such as a BMI over 30 or the presence of other weight-related health conditions.
Many insurance plans including Medicare and Medicaid will cover Mounjaro if used for type 2 diabetes. However, your copay will vary by plan and your out-of-pocket costs will be higher until you meet your deductible. Medicare Part D plans cover many diabetes medications, including Mounjaro.
Some users report that their insurance companies require prior authorization or additional documentation from their doctor to approve Mounjaro for weight loss. This can sometimes delay access or result in denied claims.
The manufacturer, Eli Lilly, offers a Mounjaro savings card to help lower the out-of-pocket cost for eligible individuals with commercial insurance. These savings programs can reduce the cost significantly for those who qualify.
Many users suggest shopping around at different pharmacies to find the best price or using online tools like GoodRx or SingleCare to compare costs. Some have also found savings by purchasing through pharmacy discount programs.
There is currently no patient assistance program or a generic alternative available for Mounjaro. However, you can consider, Zepbound, Ozempic and Wegovy (both contain semaglutide), Victoza and Saxenda (both contain liraglutide), and compounded tirzepatide as an alternative to Mounjaro.
Mounjaro dosage and administration: User tips and insights
Mounjaro (tirzepatide) comes in a pre-filled pen for subcutaneous injection. It is available in six strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg.
The starting dose is typically 2.5 mg once weekly for 4 weeks, which increases every 4 weeks until an effective maintenance dose is reached. The dosage is typically adjusted based on individual needs and treatment goals.
Mounjaro is a weekly injection administered under the skin (subcutaneously). You can inject the medication under the skin of your stomach, upper arm, or thigh.
Mounjaro comes in single-use pens, so you’ll throw the pen away after each injection. Unopened pens should be kept in the fridge until they expire, but you can store them at room temperature for up to 21 days if needed.
Mounjaro vs. other weight loss medications: User comparisons
Mounjaro is different than other weight loss drugs like Ozempic and other traditional GLP-1 agonists because it activates both receptors GLP-1 and GIP, whereas other medications only activate one receptor which is GLP-1.
Ozempic works by activating the GLP-1 receptor to control blood sugar and help in weight reduction, while Mounjaro also activates the GIP receptor to enhance metabolism, fat-burning, and weight loss.
In a study that compared Ozempic and Mounjaro, Mounjaro (in doses of 5 mg, 10 mg, and 15 mg) worked more effectively than the 1 mg dose of Ozempic. Mounjaro improved blood sugar control and helped people lose more weight. For example, people taking the 15 mg dose of Mounjaro lost nearly twice as much weight as those on Ozempic.
A study found that over 18 months, people with type 2 diabetes who took 15 mg of tirzepatide (the active ingredient in Mounjaro) lost an average of 18% of their body weight, compared to 12.4% for those taking 2.4 mg of semaglutide.
A study of people with type 2 diabetes found that the highest doses of tirzepatide led to more weight loss than the 2 mg dose of semaglutide (the active ingredient in Wegovy).
Expert opinions on Mounjaro for weight loss
Experts agree that Mounjaro can be effective for weight loss, especially when combined with a healthy lifestyle.
Research shows that people with type 2 diabetes can lose weight with Mounjaro. One study found that people with obesity lost about 15% of their body weight after taking Mounjaro for 72 weeks. Combined with diet and exercise, some people may lose up to 20% of their body weight in just over a year.
Safety and side effects
While Mounjaro can be helpful for weight loss, it does have potential side effects. Common side effects include nausea, vomiting, bloating, constipation, and diarrhea.
In rare cases, it can lead to more serious issues, like gallbladder problems, kidney issues, and depression. There are no long-term clinical studies yet, so doctors aren’t sure about potential long-term risks.
Other considerations
- Cost and accessibility: Mounjaro can be expensive, and getting it might be difficult depending on your insurance coverage.
- Ongoing use: If you lose weight with Mounjaro, you may need to continue taking the medication long-term to maintain results.
- Not a complete solution: Experts warn that Mounjaro does not address the root causes of obesity. For the best results, it should be used alongside support for nutrition, physical activity, and behavior changes.
How to get Mounjaro for weight loss
The first step in getting Mounjaro for weight loss is to consult with a healthcare provider. If your healthcare professional determines that Mounjaro is appropriate for you, they may prescribe it.
Because Mounjaro is not FDA-approved specifically for weight loss, it would be prescribed off-label, meaning the medication is used for a purpose other than its original FDA approval.
The decision to prescribe Mounjaro off-label is up to the doctor who will typically consider the guidelines for obesity (BMI equal to 30 or greater) or being overweight (BMI equal to 27 or greater) with at least one health condition related to weight).
Mounjaro is approved for
Improving glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise
Although Mounjaro is not FDA-approved for weight loss, Zepbound, a similar medication produced by the same manufacturer is FDA-approved for chronic weight management. Both medications share the same active ingredient, tirzepatide, and are made by the same company, Eli Lilly.
Tips for maximizing weight loss with Mounjaro
Here are some tips for maximizing weight loss with Mounjaro:
- Eat balanced meals: Focus on whole foods, including fruits, vegetables, lean proteins, and whole grains. Avoid processed foods and excess sugars.
- Control portion sizes: Eating smaller, more frequent meals throughout the day can help manage hunger and prevent overeating.
- Exercise regularly: Aim for at least 150 minutes of moderate-intensity exercise per week, like walking, swimming, or cycling.
- Stay hydrated: Drink plenty of water throughout the day to support your metabolism and overall health.
- Monitor your progress: Keep track of your weight, body measurements, and fitness levels regularly. This can help you see your improvements over time, even if weight loss is gradual.
- Set achievable goals: Focus on small, realistic milestones. Aim to lose 1-2 pounds per week, which is considered a healthy rate of weight loss.
- Celebrate successes: Recognize and reward yourself for reaching your goals. It can keep you motivated and encourage long-term success.
- Take Mounjaro as prescribed: Stick to your prescribed dosage and timing to get the full benefit.
- Create healthy habits: Make lifestyle changes that you can maintain in the long term. It’s not just about temporary weight loss but about creating habits that will support your health in the future.
- Be patient: Weight loss is a gradual process. Trust the process and stay committed to your routine, even when results aren’t immediate.
Mounjaro weight loss FAQs
Is Mounjaro FDA-approved for weight loss?
No, Mounjaro is not FDA-approved for weight loss. However, it is commonly prescribed off-label for weight loss to people with obesity or overweight when combined with diet and exercise.
How long does it take to see results?
You may start seeing results from Mounjaro within a few weeks, but the full effects can take a few months as your body gets used to the medication and your dose increases.
Can you use Mounjaro if you don’t have diabetes?
Yes, Mounjaro can be used for weight loss (off-label) even if you don’t have diabetes.
What happens if you stop taking Mounjaro?
If you stop taking Mounjaro, you may return to pre-treatment blood sugar levels and gradually regain the weight you lost, especially if you don’t continue with healthy eating and exercise.
Bottom line
Mounjaro has shown significant weight loss potential, with some users losing up to 20% of their body weight, especially when combined with a healthy lifestyle.
Consider making healthy lifestyle changes, like eating well, staying hydrated, and increasing physical activity to enhance the effectiveness of your treatment.
Mounjaro offers significant weight loss and blood sugar control benefits but comes with potential side effects, serious health risks, and high costs, making professional consultation crucial before use.
Always consult your healthcare provider before using Mounjaro, especially if you’re taking other medications, to ensure it’s safe and effective for you.
