How to safely switch from Ozempic to Mounjaro conversion chart
Key highlights
- Mounjaro and Ozempic are both FDA-approved medications for Type 2 diabetes and are also used off-label for chronic weight management.
- Mounjaro may be more effective than Ozempic for managing blood sugar and weight loss, with up to a 2.30% reduction in HbA1c and up to 20% body weight loss, compared to 1.86% and 10% with Ozempic.
- Switching from Ozempic to Mounjaro requires a healthcare provider to adjust the dose carefully for safety and effectiveness.
- Always consult your healthcare professional before changing medications to weigh the potential benefits and risks.
Ozempic (semaglutide) and Mounjaro (tirzepatide) are both FDA-approved GLP-1 receptor agonists used to treat type 2 diabetes. They are also used off-label for weight loss.
It is important to know the correct dosage when switching between Ozempic and Mounjaro because they have different strengths and effects. Accurate conversion ensures the medication works properly for blood sugar control.
A conversion chart is a tool used by doctors to adjust doses accurately when switching medications, taking into account differences in potency, how long the drug works, and other factors that affect how the body processes the medication.
Patients transitioning between Ozempic and Mounjaro or healthcare providers adjusting treatment may need a conversion chart to ensure the correct dosage for effective management of blood sugar levels.
Learn about the key points of a conversion chart, understand what Mounjaro and Ozempic are, and follow a simple step-by-step guide to switch safely and effectively between these two medications.
What are Mounjaro and Ozempic?
Mounjaro is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist that works similarly to Ozempic but also mimics a second hormone called GIP. Dual action helps better control blood sugar and promote weight loss, making it a strong option for managing type 2 diabetes.
Ozempic is a glucagon-like peptide 1 (GLP-1) receptor agonist that helps lower blood sugar levels by mimicking a hormone called GLP-1. This helps the body release insulin, reduce sugar production, and slow down digestion, leading to better blood sugar control and often significant weight loss.
The brand names Ozempic and Mounjaro are not approved by the FDA for weight loss, but similar medications made by the same companies with the same active ingredients are approved for weight loss under the names Wegovy and Zepbound respectively.
Both of these medications are used for glycemic control and given as weekly injections, but they work differently and have different dosages.
Understanding Mounjaro
- Dosage: Injected under the skin once a week, with doses ranging from 2.5 mg to 15 mg weekly.
- Efficacy: Mounjaro has shown strong a1c reduction and significant weight loss, often more effective than Ozempic and other appetite-reducing medications.
- Side effects: Common side effects of Mounjaro include nausea, vomiting, and diarrhea. The combination of GLP-1 and GIP receptors may cause stronger side effects, especially when starting the treatment.
- Mechanism of action: Mounjaro works by activating both GLP-1 and GIP receptors, enhancing insulin secretion, decreasing glucose production by the liver, reducing hunger and cravings, and promoting satiety leading to reduced food intake and weight loss.
In a study of over 2,500 adults with obesity, people who took 5 mg of Mounjaro for 72 weeks lost an average of 15% of their body weight. Higher doses led to even more weight loss.
Understanding Ozempic
- Dosage: Ozempic is given as a weekly subcutaneous injection. It comes in 0.5 mg, 1 mg, and 2 mg weekly doses.
- Efficacy: Ozempic can lower HbA1c levels and help with significant weight loss in people with type 2 diabetes.
- Side effects: The most common side effects of Ozempic are nausea, vomiting, diarrhea, and stomach pain. Mild allergic reactions can also happen, but these symptoms usually disappear as the body gets used to the medication.
- Mechanism of action: Ozempic boosts insulin release after meals, lowers glucagon, and slows digestion, helping control blood sugar after eating.
Clinical trials have shown that Ozempic provides cardiovascular benefits that reduce the risk of cardiovascular events such as stroke and heart attack in patients with type 2 diabetes
What is the difference between Ozempic and Mounjaro?
Ozempic, from Novo Nordisk, and Mounjaro from Eli Lilly, are both effective treatments for type 2 diabetes. However, they should not be used together or with any other GLP-1 or GIP receptor agonists.
Ozempic vs. Mounjaro
| Ozempic | Mounjaro | |
|---|---|---|
| Active ingredients: | Semaglutide | Tirzepatide |
| Mechanism of action: | GLP-1 receptor agonist that boosts insulin release. | GLP-1 and GIP receptor agonists boost insulin release, reduce hunger, and promote satiety. |
| Administration: | Once a week subcutaneously (under the skin) | Once a week subcutaneously (under the skin) |
| Efficacy: | Lowering of HbA1c levels and weight loss. | Greater reduction in HbA1c levels and more weight loss. |
| Dosage forms: | Injectable (pre-filled pen) | Injectable (pre-filled pen) |
| Available strengths: | 0.5 mg, 1 mg, 2 mg | 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg |
| Dose: | Starting dose: 0.25 mg Maintenance dose: 0.5 mg-1 mg Maximum dose: 2 mg | Starting dose: 2.5 mg Maintenance dose: 2.5 mg-15 mg Maximum dose: 15 mg |
| Blood sugar reduction (according to a 40-week study): | Reduction in HbA1c by 1.86% | Significant reduction in HbA1c up to 2.30% |
| Body weight reduction: | 10% of an individual’s total body weight. | Up to 20% of an individual’s total body weight. |
| Side effects frequency: | Nausea: 16% Vomiting: 9.2% Diarrhea: 9% Stomach pain: 7% Constipation: 5% | Nausea: 12% Diarrhea: 12% Vomiting: 9% Stomach pain: 6% Constipation: 6% |
| Cost: | $1,326 per 1, 3 mL of 2 mg/3 mL pen | $1,460 per 4, 0.5 mL of 5 mg/0.5 mL pen |
Ozempic to Mounjaro conversion chart
The doses of Ozempic and Mounjaro are different, but both are started at a low dose and gradually increased. Mounjaro has a wider range of doses than Ozempic.
The charts below are not for direct conversions but provide general guidance for the typical doses of Mounjaro and Ozempic.
Ozempic to Mounjaro conversion chart
| Ozempic | Mounjaro | |
|---|---|---|
| Starting dose: | 0.25 mg once weekly for 4 weeks | 2.5 mg once weekly for 4 weeks |
| Maintenance dose: | 0.5 mg to 1 mg once weekly | 5 mg to 12.5 mg once weekly |
| Maximum dose: | 2 mg once weekly | 15 mg once weekly |
Mounjaro to Ozempic conversion chart
| Mounjaro | Ozempic | |
|---|---|---|
| Starting dose: | 2.5 mg once weekly for 4 weeks | 0.25 mg once weekly for 4 weeks |
| Maintenance dose: | 5 mg to 12.5 mg once weekly | 0.5 mg to 1 mg once weekly |
| Maximum dose: | 15 mg once weekly | 2 mg once a week |
Ozempic and Mounjaro equivalent doses
| Ozempic dose | Equivalent Mounjaro dose | Notes |
|---|---|---|
| 0.5 mg | 2.5 mg | Starting dose for both medications is gradually increased. |
| 1 mg | 5 mg | Typical maintenance dose for both medications to keep blood sugar levels stable. |
| 2 mg | 7.5 mg | Higher doses for improved HbA1c reduction and increased weight loss. |
| - | 10 mg, 12.5 mg, 15 mg | Mounjaro provides higher doses for a more intense treatment, which are not available in Ozempic. |
Your healthcare provider will look at your current dose and any side effects before deciding on the right dose for you.
A comparative chart was published in 2023 by the American Diabetes Association to help with drug shortages. This chart compares the medications based on their effects on blood sugar.
Why to switch from Ozempic to Mounjaro
People might switch to Ozempic from Mounjaro or vice versa because of side effects. Both medications can cause nausea, vomiting, diarrhea, indigestion, stomach pain, and constipation. If you have trouble with one, you might do better with the other.
Other reasons to switch include if:
- You develop heart disease (Ozempic helps lower the risk of heart problems for people with type 2 diabetes and heart disease)
- You want to lose more weight
- Insurance or cost is an issue
- Either of the medications is not available (drug shortages)
- Your blood sugar is uncontrolled
- You have an allergy to either of the medications
Can you take Ozempic and Mounjaro together?
No, you should not take Ozempic and Mounjaro together. Both medications work in similar ways to lower blood sugar, so using them at the same time could increase the risk of side effects. It is best to talk to your doctor to decide which one is right to decide which medication should be included in your treatment plan.
How to switch from Ozempic to Mounjaro
Switching from Ozempic to Mounjaro requires careful planning to ensure the change goes smoothly and that your blood sugar remains stable. Here’s a simple guide to help you switch safely.
- Consult your doctor: Always talk to your doctor before making any changes to your medication. They will guide you on how to start Mounjaro safely and may suggest a gradual dose adjustment.
- Watch for side effects: Both medications have similar side effects, but Mounjaro may cause stronger side effects due to its extra ingredient. You might experience stomach issues or low blood sugar symptoms like dizziness, shaking, or confusion. Contact your doctor if symptoms get worse.
- Monitor blood sugar and weight: Keep track of your blood sugar levels and weight during the switch to ensure that the new medication is working properly. Report any significant changes to your doctor.
How to switch from Ozempic to Mounjaro
| Time passed since the last dose of Ozempic | When to take the first dose of Mounjaro |
|---|---|
| 1 day | In 6 days |
| 2 days | In 5 days |
| 3 days | In 4 days |
| 4 days | In 3 days |
| 5 days | In 2 days |
| 6 days | In 1 day |
| 7 or more days | Today |
Speak with your healthcare provider
Before changing your diabetes medication, it is important to consult your doctor. They will assess your health, including your blood sugar levels (HbA1c levels), current weight, and other medical conditions, to analyze if switching to Mounjaro is right for you. Your doctor will also guide you on the right dose and how to manage any potential side effects if they occur. Make sure to ask about the cost and insurance coverage for Mounjaro.
Monitor blood sugar levels
After switching from Ozempic to Mounjaro, keep a close eye on your blood sugar levels, especially in the first few weeks. This helps to ensure the new medication is working well and not causing low blood sugar (hypoglycemia) or other issues. Keep track of your doses and report to your doctor if you notice any significant adverse effects.
Monitor side effects
Both Ozempic and Mounjaro can cause gastrointestinal side effects like nausea, vomiting, and diarrhea, especially when you start or change the dose. When switching to Mounjaro, these side effects may be stronger.
To reduce discomfort or prevent potential adverse events:
- Start with the lower dose: Your doctor will likely begin with a small dose to minimize side effects.
- Take it with food: This can help with nausea.
- Drink plenty of water: Staying hydrated helps with stomach symptoms.
Talk to your doctor if side effects are severe or last for long. They might adjust your dose or suggest other treatments.
Consider lifestyle changes
Switching medications is only one part of managing type 2 diabetes. To get the most out of Mounjaro, make healthy lifestyle changes like eating a balanced diet, exercising regularly, and maintaining a healthy weight. These habits can help your medication work better and improve your overall health.
Bottom line
Transitioning from Ozempic to Mounjaro can lead to better blood sugar control and more weight loss, as Mounjaro has shown greater reductions in HbA1c and up to 20% weight loss.
Using a conversion chart helps doctors adjust the Mounjaro dose correctly based on your current Ozempic dosage for safe and effective treatment.
Consider making healthy lifestyle changes, like eating well and staying active, to enhance the effectiveness of your treatment.
Close monitoring of blood glucose levels and side effects is crucial during the switch, and working with your healthcare provider ensures a smooth transition and better diabetes management.
